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There is currently much discussion as to whether probabilistic (top–down) or possibilistic (bottom–up) approaches are the most appropriate to estimate potential future climate impacts. In a context of deep uncertainty, such as future climate, bottom-up approaches aimed at assessing the sensitivity and vulnerability of systems to changes in climate variables have been gaining ground. A refined framework is proposed here (in terms of coherence, structure, uncertainty, and results analysis) that adopts the scenario–neutral method of the bottom–up approach, but also draws on some elements of the top–down approach. What better guides the task of assessing the potential hydroclimatological impacts of changing climatic conditions in terms of the sensitivity of the systems, differential analysis of climatic stressors, paths of change, and categorized response of the scenarios: past, changing, compensatory, and critical condition. The results revealed a regional behavior (of hydroclimatology, annual water balances, and snow) and a differential behavior (of low flows). We find, among others, the plausible scenario in which increases in temperature and precipitation would generate the same current mean annual flows, with a reduction of half of the snow, a decrease in low flows (significant, but differentiated between basins), and a generalized increase in dry events.