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Placement of large wood is a common stream restoration technique in western North America and increasingly in other parts of the world. Considerable information exists on response of anadromous salmonids in small (< 15 m bankfull width) coastal streams of western North America, but limited information exists on anadromous fish response to wood placement in larger streams or in the more arid interior Columbia River Basin. An extensive post-treatment design was used to sample 29 large wood placement projects to determine their physical and biological effectiveness. We sampled paired treatment and control reaches that were approximately 20 times longer than bankfull width and quantified fish abundance and habitat attributes during summer. Proportion of pool area, number of pools, large wood (LW), and pool forming large wood were significantly higher in paired treatment than control reaches. Juvenile Chinook salmon (Oncorhynchus tshawytscha), steelhead (O. mykiss) coho salmon (O. kisutch), and cutthroat trout (O. clarkii) abundances were significantly higher in treatment than control reaches, but no significant responses were detected for mountain whitefish (Prosopium williamsoni) or dace (Rhinichthys spp.). Chinook and coho responses were positively correlated with LW and pool area suggesting wood placement produced reach-scale increases of juvenile salmonid abundance.