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Significance In the model simulations analyzed here, large high-latitude volcanic eruptions have global and long-lasting effects on climate, altering the spatiotemporal characteristic of the El Niño–Southern Oscillation (ENSO) on both short (<1 y) and long timescales and affecting the strength of the Atlantic Meridional Overturning Circulation (AMOC). In the first 8–9 mo following the start of the eruption, El Niño-like anomalies develop over the equatorial Pacific. The large high-latitude eruptions also trigger a strengthening of the AMOC in the first 25 y after the eruption, which is associated with an increase in ENSO variability. This is then followed by a weakening of the AMOC lasting another 30–35 y, associated with decreased ENSO variability. , Large volcanic eruptions can have major impacts on global climate, affecting both atmospheric and ocean circulation through changes in atmospheric chemical composition and optical properties. The residence time of volcanic aerosol from strong eruptions is roughly 2–3 y. Attention has consequently focused on their short-term impacts, whereas the long-term, ocean-mediated response has not been well studied. Most studies have focused on tropical eruptions; high-latitude eruptions have drawn less attention because their impacts are thought to be merely hemispheric rather than global. No study to date has investigated the long-term effects of high-latitude eruptions. Here, we use a climate model to show that large summer high-latitude eruptions in the Northern Hemisphere cause strong hemispheric cooling, which could induce an El Niño-like anomaly, in the equatorial Pacific during the first 8–9 mo after the start of the eruption. The hemispherically asymmetric cooling shifts the Intertropical Convergence Zone southward, triggering a weakening of the trade winds over the western and central equatorial Pacific that favors the development of an El Niño-like anomaly. In the model used here, the specified high-latitude eruption also leads to a strengthening of the Atlantic Meridional Overturning Circulation (AMOC) in the first 25 y after the eruption, followed by a weakening lasting at least 35 y. The long-lived changes in the AMOC strength also alter the variability of the El Niño–Southern Oscillation (ENSO).